SOTA 08: Principles and Practice of Living Donor Exchange
Chair
Lloyd Ratner
Dr. Lloyd E. Ratner is Professor of Surgery and the Director of Renal and Pancreatic Transplantation at Columbia University/New York-Presbyterian Hospital. Throughout Dr. Ratner’s academic career, he has introduced novel ideas that have profoundly impacted clinical practice in the field of transplantation, and he has been recognized both nationally and internationally for his many contributions. He has been a leading innovator in renal transplantation for the past two decades. In 1993 Dr. Ratner performed the first dual renal transplant. Subsequently, (in collaboration with Dr. Louis Kavoussi) he performed the first laparoscopic donor nephrectomy in 1995, and set the stage for its widespread adoption by the transplant community. Dr. Ratner has also made significant contributions in overcoming immunologic incompatibilities that formerly prohibited transplantation. He authored the plasmapheresis/low dose IVIg protocol for alloantibody desensitization in 1998. And while on the faculty at Johns Hopkins University in 2001, Dr. Ratner orchestrated one of the first paired-kidney exchanges in the United States. More recently Dr. Ratner has been a leading proponent of including compatible donor/recipient pairs in paired kidney exchanges. Dr. Ratner received his M.D. for Hahnemann University School of Medicine. His general surgery training was obtained at Long Island Jewish Medical Center. He completed a Fellowship in Transplantation Surgery and Immunology at Washington University.
Chair
Dorry Segev
Dr. Segev is an abdominal transplant surgeon and the Director of Clinical Research for the Transplant Surgery division. His clinical focus is minimally invasive live donor surgery and incompatible organ transplantation. His research utilizes advanced statistical methods for mathematical modeling and simulation of medical data, analysis of large healthcare datasets, and outcomes research.
He has made numerous significant contributions to the field of transplantation including development of a mathematical model to facilitate a nationwide Kidney Paired Donation program in both the United States and in Canada. Dr. Segev is an NIH Clinical Research Scholar, an NIH/NIA Paul Beeson Scholar, an American Geriatrics Society Dennis Jahnigen Scholar, an invited member of the United Network for Organ Sharing Kidney Committee, and a Doris Duke Clinical Scientist Development Award recipient for his groundbreaking work in clinical decision-making for patients over 65 with renal failure. He also received the 2009 Julius Jacobson Promising Investigator Award from the American College of Surgeons, an award given to only one surgeon annually.
Dr. Segev has authored more than 100 articles, and is regularly invited to review articles for journals such as New England Journal of Medicine, JAMA, American Journal of Transplantation, Annals of Surgery, Journal of the American Society of Nephrology, Annals of Internal Medicine, and others. He is an Associate Editor for the American Journal of Transplantation as well as the journal Liver Transplantation. Dr. Segev's work has been featured in TIME magazine, Reader's Digest, the Discovery Channel, US News & World Report, Wall Street Journal, and the New York Times.
Marry de Klerk
Marry de Klerk is employed by the Erasmus Medical Center and the Dutch Transplant Foundation as the national coordinator of the Dutch Living Donor Kidney Exchange Program.
In 2002, she joined the department of Internal Medicine - Kidney Transplantation (head Professor W. Weimar) of the Erasmus Medical Center Rotterdam as a social worker and transplant coordinator for the living kidney donation program. She became involved in the preparation committee for a national kidney exchange program in 2003. As part of these preparations she conducted a pilot study on acceptability and feasibility of such a program among potential candidates. She explored under which conditions a kidney exchange program could be realized and described the various ethical issues inherent in a kidney exchange program. She developed a protocol describing rules for registration, allocation, immunological, surgical and follow-up procedures. The Dutch Living Donor Kidney Exchange Program started in January 2004 and she became the national coordinator in cooperation with all eight kidney transplantation centers in the Netherlands and the National Reference Laboratory for Histocompatibility. Since 2004 she has published widely and given many presentations on the development and evaluation of the conditions, allocation rules, and computer matching and logistic of the program. Currently, she is pioneering ideas to expand the Dutch Living Donor Kidney Exchange Program with new alternatives such as: a Domino Paired Kidney Donation Program and an Altruistic Unbalanced Paired Kidney Exchange Program.
Dr. de Klerk earned her bachelor's degree in social work and social service from the University of Professional Education, Faculty of Health and Social Studies, Rotterdam in 1997. After working at various departments at the hospital she received her doctorate from the Erasmus University Rotterdam, Faculty of Medicine and Health Sciences in April 2010.
Ed Cole
Dr. Edward Cole received his Bachelor of Science and Master of Science from the University of Toronto in 1972 and 1973, respectively, and his MD from Memorial University of Newfoundland in 1975. In 2001 he was appointed as Director, Division of Nephrology, University Health Network & Mount Sinai Hospital and in 2007 became the Amgen Professor of Nephrology. He is currently Professor of Medicine and, from 1996-2006; he was the Director of the Division of Nephrology, University of Toronto. He is founder and Chair of The Canadian Transplantation Society Kidney Working Group and Chair of the Steering Committee for National Kidney Registries. Dr. Cole was appointed Physician-in-Chief, University Health Network in May, 2010, and holds the Dr. Charles H. Hollenberg Chair in Medicine. His major research interests are in immunosuppressive drugs and clinical trials in renal transplantation with over 130 peer-reviewed publications.